Witryna10 cze 2015 · About ISTH0036 ISTH0036 is a locked nucleic acid-modified antisense oligonucleotide selectively targeting the messenger ribonucleic acid (mRNA) of TGF … Witryna30 wrz 2024 · The leadership team will be focused on developing Isarna’s lead product ISTH0036 as a promising therapeutic candidate for diseases of the eye. “Isarna has reached an exciting stage of development for its lead program, ISTH0036, which has broad applicability in a range of ophthalmology indications,” said Claus Schalper, …
Potent and selective antisense oligonucleotides targeting the ...
Witryna31 sie 2024 · Isarna has developed ISTH0036 to target the transforming growth factor-beta (TGF-β), a protein which is chronically elevated in ophthalmic, fibrotic, … WitrynaISTH0036 is a 14-mer phosphorothioate Locked Nucleic Acid- (LNA) modified antisense oligonucleotide gapmer, targeting the sequence of TGF-β2 mRNA and was developed for therapeutic intervention in ocular diseases. It was shown to effectively and potently downregulate target elecomマウス 動かない
Isarna Presents Positive Preclinical Results Supporting …
Witryna1 kwi 2024 · This review provides a detailed insight into the recent developments and clinical trials that have been conducted for several gene-silencing therapies, including ISTH0036, SYL040012, SYL1001, PF-04523655, Sirna-027, QR-110, QR-1123, QR-421a and IONIS-FB-L RX in glaucoma, dry eye disease, age-related macular … Witryna10:52 Long-term safety and efficacy of ISTH0036, a selective TGF-β2 blocking antisense in preclinical and clinical studies. All Faculty. 10:57 Discussion. See full interactive programme. Programme details may be subject to change. Please refer to the interactive programme for the most up to date details. Witryna35 ETDRS letters at Scr (except when due to conditions whose surgery may improve visual acuity, e.g., cataract) 3.nAMD diagnosed for more than 9 mon 4.Poor quality of SD-OCT images at Scr or BL 5.Central subfield of the study eye affected by geographic atrophy assessed by OCT, color fundus photography (CFP) and fundus … elecom マウス 分解