This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mutation was found to be responsible for a novel form of ciliopathy … Meer weergeven Intraflagellar transport protein 88 homolog is a protein that is encoded by the IFT88 gene. Meer weergeven IFT88 has been shown to interact with BAT2 and WDR62. WDR62 is required for IFT88 localization to the cilia basal body and the cilia axoneme. Meer weergeven • Murcia NS, Sweeney WE, Avner ED (1999). "New insights into the molecular pathophysiology of polycystic kidney disease". Kidney Int. 55 (4): 1187–97. doi: • Moyer JH, … Meer weergeven Web14 jan. 2024 · We found, for example, that most IFT88 protein is lost in Ift88 conditional mutants as expected. However, the cilia persist on adult neurons within the brain in the …
Frontiers Non-ciliary Roles of IFT Proteins in Cell Division and ...
Web15 feb. 2024 · Gene Snapshot Gene Group Also Known As IFT88, osm-5 Key Links Genomic Location Cytogenetic map 39E2-39E2 Sequence location 2L:21,578,292..21,589,423 [-] Recombination map (full details) 2-54 RefSeq locus NT_033779 REGION: 21578292..21589423 Sequence Get Sequence Get Decorated … Web18 mei 2024 · Intraflagellar transport (IFT) is an evolutionarily conserved mechanism that is indispensable for the formation and maintenance of cilia and flagella; however, the … server boosts pet sim x
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Web27 mrt. 2011 · In mitosis, IFT88 is part of a dynein1-driven complex that transports peripheral microtubule clusters containing microtubule-nucleating proteins to spindle … Web10 mei 2024 · The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is … Web15 apr. 2024 · IFT88 mediates angiogenesis by regulating the migration, polarization, proliferation, and oriented division of vascular endothelial cells. Further mechanistic … the tech juggernaut