Dithiolopyrrolones
WebMar 7, 2024 · Dithiolopyrrolones (DTPs) are an underexplored class of disulfide-containing natural products, which exhibit potent antimicrobial activities against … WebProcédés innovants pour la production de dithiolopyrrolones par Saccharothrix algeriensis NRRLB-24137. 2024 • Alaa Hamdar. Download Free PDF View PDF. Bulletin de l'Académie Lorraine des Sciences, N°50, 2011. 2012 • Xavier …
Dithiolopyrrolones
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WebJul 8, 2024 · Dithiolopyrrolones, which possess a unique pyrrolinonodithiole skeleton linked to two variable acyl groups, are a group of natural antibiotics that have showed strong broad-spectrum activities towards various Gram-positive and Gram-negative bacteria, protozoa, yeast, pathogenic micro-fungi, and also against different cell lines involved in … WebAug 25, 2024 · Besides, dithiolopyrrolones (DTPs), a class of hetero-bicyclic natural products with disulfide linkage, are known to exhibit potent antimicrobial activities against multidrug-resistant pathogens. The role of DTPs in therapeutics ranges from antibiotic activity to potent antiangiogenic effects. They are also characterized by a disulfide bridge ...
WebAug 23, 2024 · Nature Chemical Biology Jul 2024. Thiolutin is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Its biological targets are not known. We show that reduced ... WebNov 1, 2006 · However, the production levels of these five dithiolopyrrolones were shown to be modified by the addition of amino acids as precursors to a basal semi-synthetic …
WebFeb 27, 2024 · Dithiolopyrrolones (DTPs) are disulfide-containing natural products with broad-spectrum antimicrobial activity. Studies have shown that DTPs inhibit several essential cellular processes, but their molecular mechanism has remained elusive. WebJan 18, 2024 · DtpM catalyzes efficient conversion of holomycin to thiolutin, exhibits broad substrate scope toward dithiolopyrrolones, and has high thermal stability. In addition, sequence similarity network analysis …
WebFeb 12, 2024 · Dithiolopyrrolones are microbial natural products containing a disulfide or thiosulfonate bridge embedded in a unique bicyclic structure. By interfering with zinc ion …
WebMay 1, 2011 · Dithiolopyrrolones are known to be produced by several species of Streptomyces, Xenorhabdus and Alteromonas. The actinomycete S. algeriensis produces five dithiolopyrrolones in the basic medium (without precursors): thiolutin, iso-butyryl-pyrrothine, butanoyl-pyrrothine, senecioyl-pyrrothine and tigloyl-pyrrothine ( Lamari, … think sonne und mondWebMar 20, 2024 · Efficiency of Saccharothrix algeriensis NRRL B-24137 and Its Produced Antifungal Dithiolopyrrolones Compounds to Suppress Fusarium oxysporum-Induced Wilt Disease Occurring in Some Cultivated Crops SpringerLink Home Arabian Journal for Science and Engineering Article Research Article - Biological Sciences Published: 20 … think songsWebFeb 16, 2024 · Chemical genomics screen identifies iron and zinc uptake mutants with increased sensitivity toward dithiolopyrrolones. Fitness scores of the chemical … think sonoWebOct 17, 2013 · Dithiolopyrrolones are a group of potent antibiotic natural products that have been found in both Gram-negative and Gram-positive bacteria. They consist of a unique pyrrolinonodithiole (4 H - [1,2] dithiolo [4,3- b] pyrrol-5-one) chromophore [ 4 ]. think sound effectWebAbstract Aims: The hypothetical dithiolopyrrolone biosynthetic pathway includes a final step of pyrrothine nucleus acylation. The presence of an enzymatic activity catalysing this reaction was investigated in Saccharothrix algeriensis NRRL B-24137. think source electronics limitedWebJan 18, 2024 · Les dithiolopyrrolones ne sont produits que pendant l'idiophase. La biosynthèse de ces antibiotiques est soumise à la régulation par les acides organiques … think source llcWebMar 18, 2024 · Dithiolopyrrolones are a class of structurally intriguing natural products with broad antibacterial spectrum . Most of the analogues are characterized by a unique bicyclic pyrrolinonodithiole, with the differences in the substitution groups on N -4 and N -7 positions of the holothin core [ 35 , 36 ]; however, thiolopyrrolone A is the first ... think sound 1